BMC2 Data Presented During ACC.25 in Chicago

BMC2 data were shared during four presentations at ACC.2025, March 29-31, 2025, in Chicago.

Dr. Matthew J. Lacey presented the poster, “The Hard Challenge of Calcific Saphenous Vein Graft Stenosis: The Largest Reported Experience with IVL and/or Mechanical Atherectomy - Insights from BMC2.”

Interventions on calcific saphenous vein grafts (SVG) are traditionally considered extreme risk and were often avoided in clinical practice. With the aging of the patient population and availability of new technology, select operators have reported on use of calcium modification strategies in SVG PCI. Dr. Lacey and co-authors used BMC2 data to assess the safety and clinical outcomes of atherectomy and lithotripsy (IVL) in SVG PCI.

They concluded that, while infrequent, SVG calcific stenosis is increasingly being treated with atherectomy or IVL with high and potentially acceptable complication rates. To the best of their knowledge, this is the largest analysis of lithotripsy and atherectomy during SVG PCI and should help guide physicians encountering these hard-to-treat lesions in clinical practice.

Poster co-authors are Milan Seth, MS; Eric Cantey, MD; Elizabeth J. Pielsticker, MD; Joseph Chattahi, MD; Mark Zainea, MD; Dileep Arora, MD; Ashok K. Kondur, MD; Brett Wanamaker, MD; Devraj Sukul, MD; Hitinder S. Gurm, MD.

Poster co-authors are Milan Seth, MS; Eric Cantey, MD; Elizabeth J. Pielsticker, MD; Joseph Chattahi, MD; Mark Zainea, MD; Dileep Arora, MD; Ashok K. Kondur, MD; Brett Wanamaker, MD; Devraj Sukul, MD; Hitinder S. Gurm, MD.

Learn more by viewing the poster on bmc2.org.

 

Dr. David E. Hamilton presented the moderated poster, “BMC2 Machine Learning Risk Prediction of Post-Discharge Mortality and Readmission After PCI: The Perilous Road Ahead.”

Readmissions following percutaneous coronary intervention (PCI) are frequent, costly, and often preventable.

Accurately identifying patients at high risk for readmission or death after discharge remains challenging.

Dr. Hamilton and his colleagues utilized BMC2 and Michigan Value Collaborative (MVC) data and feedback from the BMC2 PCI Patient Advisory Council to develop a risk-prediction model to detect patients most vulnerable to adverse events after PCI.

The BMC2 Machine Learning Risk-Prediction Model accurately predicts 30-day readmission and 1-year mortality for elderly patients after PCI.

Co-authors are Jeremy Albright, PhD; Milan Seth, MS; Devraj Sukul, MD; and Hitinder S. Gurm, MD

A PDF of the poster, and a desktop version of the risk prediction model are available on bmc2.org.

 

Dr. Aaron Lopacinski presented the poster, “Utilization of Invasive Hemodynamic Monitoring at Time of Mechanical Circulatory Support Implantation for the Treatment of Acute Myocardial Infarction Cardiogenic Shock: Insights from the BMC2 Registry.”

Acute myocardial infarction cardiogenic shock is the inability of the heart to provide blood to the body in the setting of a heart attack.  It occurs in 8-10% of heart attacks and carries a mortality rate of 50%.  A recent trial suggests a mortality benefit of a micro-axial flow pump, a pump that allows the heart to relax and provide blood flow to the rest of the body, despite an increased risk of device-related complications.

A review of BMC2 data found that variations in the care for acute myocardial infarction cardiogenic shock strongly suggest that there is a need to develop standards of care and protocols to ensure early recognition, risk stratification, and treatment of acute myocardial infarction cardiogenic shock. 

These findings lay the groundwork for future efforts needed to streamline and standardize the care of patients with acute-myocardial infarction.  The development of hub-and-spoke models of care will lead to multi-disciplinary and inter-institutional collaboration with the goal of improved patient outcomes.

Co-authors are Milan Seth, MS; Eric Cantey, MD; Siddharth Gandhi, DO; Brett Wanamaker, MD; Mir B. Basir, DO; Amir Kaki, MD; Ryan Madder, MD; Devraj Sukul, MD; and Hitinder Gurm, MD.

View a PDF of the poster on bmc2.org.

 

Dr. Elias Dayoub presented the poster, “Still Here, ISR in Contemporary Practice: Insights from the BMC2 Registry.”

In-stent restenosis (ISR) remains the leading cause of target lesion failure following percutaneous coronary intervention (PCI).

Study authors reviewed BMC2 data on ISR incidence, time-to-repeat PCI, treatment modality, and target lesion among PCI procedures performed from April 2018 through March 2024.

They found that:

• ISR PCI is common, accounting for nearly 10% of all PCI performed.
• The median time to repeat PCI for ISR is 39 months.
• Left main PCI has the shortest median time to repeat PCI for ISR – 17 months.

Co-authors are Milan Seth, MS; Eric Cantey, MD; John Collins, MD; Eric Walchak, DO; Joseph Gibbs, MD; Siddarth Gandhi, DO; Brittany Fuller, MD; Osman Abdulfatah, MD; Devraj Sukul, MD; and Hitinder Gurm, MD.

View a PDF of the poster on bmc2.org.